Juan Carlos de la Torre Selected Research

Attenuated Vaccines

1/2020	A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region.
1/2020	A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene.
1/2020	Development of Reverse Genetics for the Prototype New World Mammarenavirus Tacaribe Virus.
1/2016	Novel strategies for development of hemorrhagic fever arenavirus live-attenuated vaccines.
7/2015	Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines.
1/2012	Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner.
6/2006	Envelope exchange for the generation of live-attenuated arenavirus vaccines.

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Juan Carlos de la Torre Research Topics

Disease

24	Infections 07/2021 - 03/2003
12	Virus Diseases (Viral Diseases) 10/2021 - 12/2004
10	Arenaviridae Infections 01/2018 - 03/2004
7	Persistent Infection 10/2016 - 06/2002
6	Lassa Fever (Fever, Lassa) 01/2021 - 10/2004
5	COVID-19 10/2021 - 01/2020
4	Vesicular Stomatitis 01/2020 - 06/2003
4	Fever (Fevers) 01/2020 - 06/2006
2	Inflammation (Inflammations) 01/2018 - 01/2016
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2021
1	Pneumonia (Pneumonitis) 01/2021
1	American Hemorrhagic Fever (Bolivian Hemorrhagic Fever) 01/2020
1	Herpesviridae Infections (Herpesvirus Infection) 01/2020
1	Severe Acute Respiratory Syndrome 01/2020
1	Human Influenza (Influenza) 01/2020
1	Zika Virus Infection 01/2020
1	Multiple Sclerosis 01/2019
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019
1	Systemic Scleroderma (Systemic Sclerosis) 01/2018
1	Rheumatoid Arthritis 01/2018
1	Alzheimer Disease (Alzheimer's Disease) 01/2018
1	Splenomegaly 01/2018
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2017
1	Coinfection 11/2015
1	Neoplasms (Cancer) 02/2015
1	Nervous System Diseases (Neurological Disorders) 08/2013
1	Disease Progression 04/2013
1	Viral Meningitis 08/2011
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 11/2010
1	Bacterial Infections (Bacterial Infection) 01/2006
1	Emerging Communicable Diseases (Emerging Infectious Diseases) 02/2004
1	Foot-and-Mouth Disease 03/2003

Drug/Important Bio-Agent (IBA)

17	VaccinesIBA 01/2021 - 10/2004
15	Antiviral Agents (Antivirals)IBA 07/2021 - 03/2003
9	Proteins (Proteins, Gene)FDA Link 10/2021 - 06/2003
9	Ribavirin (Virazole)FDA LinkGeneric 01/2020 - 12/2008
7	Attenuated VaccinesIBA 01/2020 - 06/2006
7	Interferon Type IIBA 01/2018 - 11/2010
5	InterferonsIBA 01/2018 - 01/2006
4	Glycoproteins (Glycoprotein)IBA 01/2021 - 06/2003
4	AntigensIBA 01/2021 - 12/2004
4	RNA (Ribonucleic Acid)IBA 01/2021 - 03/2003
2	AntibodiesIBA 10/2021 - 10/2016
2	Pharmaceutical PreparationsIBA 07/2021 - 02/2012
2	NucleoproteinsIBA 01/2021 - 08/2012
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 09/2006
2	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2020 - 11/2015
2	CytokinesIBA 01/2018 - 01/2015
2	Neutralizing AntibodiesIBA 10/2016 - 10/2004
2	Interleukin-10 (Interleukin 10)IBA 01/2016 - 08/2011
2	Peptide Hydrolases (Proteases)FDA Link 02/2011 - 12/2004
1	remdesivirIBA 07/2021
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	InflammasomesIBA 01/2021
1	Metformin (Glucophage)FDA LinkGeneric 01/2021
1	3,5-diisopropylsalicylic acid (DIPS)IBA 01/2021
1	Codon (Codons)IBA 01/2020
1	enhanced green fluorescent proteinIBA 01/2020
1	Dimethyl FumarateIBA 01/2019
1	EnzymesIBA 01/2018
1	Nucleic AcidsIBA 01/2018
1	Phospholipases (Phospholipase)IBA 01/2018
1	2- (4- (5- (3,4- diethoxyphenyl)- 1,2,4- oxadiazol- 3- yl)- 2,3- dihydro- 1H- inden- 1- yl amino)ethanolIBA 01/2017
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2016
1	CalciumIBA 10/2016
1	PerforinIBA 10/2016
1	EpitopesIBA 11/2015
1	Antigen-Antibody Complex (Immune Complex)IBA 02/2015
1	ChemokinesIBA 01/2015
1	pyrimidineIBA 01/2014
1	Valproic Acid (Depakote)FDA LinkGeneric 08/2013
1	Volatile Fatty AcidsIBA 08/2013
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/2012
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 08/2012
1	PF-429242IBA 02/2012
1	Messenger RNA (mRNA)IBA 01/2012
1	Fluorouracil (Carac)FDA LinkGeneric 01/2012
1	Monoclonal AntibodiesIBA 08/2011
1	Green Fluorescent ProteinsIBA 08/2011
1	Purine NucleosidesIBA 07/2011
1	RibonucleoproteinsIBA 04/2011
1	Alanine (L-Alanine)FDA Link 04/2011
1	site 1 membrane-bound transcription factor peptidaseIBA 03/2011
1	Metalloproteases (Metalloproteinases)IBA 02/2011
1	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2010
1	Pathogen-Associated Molecular Pattern MoleculesIBA 11/2010
1	Transcription Factors (Transcription Factor)IBA 11/2010
1	Pattern Recognition ReceptorsIBA 11/2010
1	Viral ProteinsIBA 06/2008
1	Interferon-betaIBA 09/2006
1	Liposomes (Liposome)IBA 09/2006
1	UbiquitinIBA 01/2006
1	UbiquitinsIBA 12/2004
1	SR-ATIBA 06/2003
1	Complementary DNA (cDNA)IBA 06/2003
1	MutagensIBA 03/2003

Therapy/Procedure

10	Therapeutics 07/2020 - 02/2004
7	Off-Label Use 01/2020 - 07/2011
3	Drug Therapy (Chemotherapy) 01/2017 - 01/2016
1	RNAi Therapeutics 09/2005